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secukinumab
Used for Psoriasis, Psoriatic Arthritis, Non-radiographic Axial Spondyloarthritis, Ankylosing Spondylitis, Hidradenitis Suppurativa
Used for Psoriasis, Psoriatic Arthritis, Non-radiographic Axial Spondyloarthritis, Ankylosing Spondylitis, Hidradenitis Suppurativa
Cosentyx (secukinumab) is a monoclonal antibody known as an interleukin 17 (IL-17) inhibitor. It's used to treat several inflammatory conditions, including plaque psoriasis, ankylosing spondylitis, and hidradenitis suppurativa. Cosentyx (secukinumab) comes as a pre-filled pen and syringe, and is typically injected under the skin monthly. It can also be given as an infusion through the veins by a healthcare provider for certain conditions, usually in a clinic setting. Side effects aren't common, but can include the common cold and diarrhea.
Reviewed by:
Robert Chad Hakim, PharmD, BCCCP
Connie Zheng, PharmD
Last reviewed on January 22, 2024
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What is Cosentyx (secukinumab)?
What is Cosentyx (secukinumab) used for?
Plaque psoriasis (PsO) in people ages 6 years and older
Psoriatic arthritis (PsA) in people ages 2 years and older who weigh at least 33 lbs
Ankylosing spondylitis (AS) in adults
Non-radiographic axial spondyloarthritis (nr-axSpA) in adults
Enthesitis-related arthritis in people ages 4 years and older who weigh at least 33 lbs
Hidradenitis suppurativa in adults
How Cosentyx (secukinumab) works
Cosentyx (secukinumab) is a monoclonal antibody that works as an interleukin inhibitor. It blocks a protein in your immune system called interleukin-17 (IL-17), which tends to be overly active in certain inflammatory conditions. In doing so, Cosentyx (secukinumab) lowers swelling, pain, and inflammation.
Drug Facts
Common BrandsCosentyx
Drug ClassInterleukin 17 (IL-17) inhibitor
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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Avg retail price
$12961.58
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What are the side effects of Cosentyx (secukinumab)?
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
Note: Side effects listed were reported by adults who took Cosentyx (secukinumab) for PsO in clinical trials.
Other Side Effects
Serious Side Effects
Contact your healthcare provider immediately if you experience any of the following.
Source:DailyMed
The following side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Dry, itchy, scaly patches of skin that blister or peel
- Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
- Sudden or severe stomach pain, bloody diarrhea, fever, nausea, vomiting
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Diarrhea
- Runny or stuffy nose
- Sore throat
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Pros and cons of Cosentyx (secukinumab)
Pros
Works well to treat several different inflammatory problems
Injected monthly (after the loading doses)
Available as a prefilled syringe or Sensoready pen for easy at-home injections
Can be used in children (for plaque psoriasis, psoriatic arthritis, and enthesitis-related arthritis)
Cons
Only available as injections
Raises the risk of infections
Can worsen inflammatory bowel disease (IBD) (e.g., ulcerative colitis or Crohn's disease) symptoms
Pens and prefilled syringes not appropriate for those with latex allergy
Pharmacist tips for Cosentyx (secukinumab)
Receiving Cosentyx (secukinumab) can raise your risk for an infection that's difficult to treat. If you get sick, your provider might ask you to stop Cosentyx (secukinumab) until your infection is treated. Let your provider know if you've symptoms such as fever, body aches, chills, and cough.
Live vaccines aren't recommended after you've started Cosentyx (secukinumab). Before you receive any vaccines, let your provider know you're taking Cosentyx (secukinumab) so they can let you know if it's safe for you to get vaccinated.
Don't breastfeed while taking Cosentyx (secukinumab) unless you've discussed the benefits and risks of doing so with your provider. Cosentyx (secukinumab) hasn't been well-studied during breastfeeding, but limited research suggests it's unlikely to cause harm to a nursing baby.
Store Cosentyx (secukinumab) pens or prefilled syringes in the refrigerator in the original carton and protect it from light.
If needed, you can store Cosentyx (secukinumab) pens or prefilled syringes at room temperature for up to 4 days. If you do store it at room temperature, make sure to write down the new 4-day expiration date.
If Cosentyx (secukinumab) pens or prefilled syringes has been sitting at room temperature for less than 4 days, you can put it back in the fridge one time. If you do, the medication can be used up until the manufacturer's expiration date on the package.
Tips for using [Cosentyx (secukinumab) injections under the skin at home:
Cosentyx (secukinumab) is available as a Sensoready Pen, Unoready Pen, and prefilled syringe. If appropriate, your provider can train you or your caregiver to give Cosentyx (secukinumab) injections at home. Refer to the instructions for use, depending on the product you have for how to properly inject the medication.
When you're ready for yourCosentyx (secukinumab) dose, take the medication out of the carton and lay it on a flat surface to warm up. This should take about 15 to 30 minutes (for the Sensoready Pen and 75 mg and 150 mg prefilled syringes) or 30 to 45 minutes (for the Unoready Pen and 300 mg prefilled syringe). Don't try to warm up the medication any other way (e.g., microwave or run under hot water) because this can damage it. Don't freeze or shake the medication either.
Always check that the medication is clear, colorless or slightly yellow, and doesn't have particles. If Cosentyx (secukinumab) is discolored, cloudy, or has particles, don't use it. Contact your pharmacy about a replacement.
You can self-inject into the front of your thighs or stomach at least 2 inches away from your belly button). If someone else is giving you the injection, they can inject Cosentyx (secukinumab) into the outside of your upper arms.
Don't inject Cosentyx (secukinumab) into skin that is tender, bruised, red, hard, or in an area affected by psoriasis. Rotate the site of injection with each administration to avoid any irritation. Never inject it into your muscle or vein.
After your Cosentyx (secukinumab) injection, place the medication in a sharps container or a heavy-duty plastic container (e.g., empty milk carton, laundry detergent bottle) to lower the risk of needle-stick injuries. Don't throw away syringes or autoinjectors into your trash can. Visit the FDA's website for guidance on how to safely throw away your sharps container in your specific state.
Frequently asked questions about Cosentyx (secukinumab)
Is Cosentyx (secukinumab) a steroid?
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No, Cosentyx (secukinumab) isn't a steroid. But rather, it's a monoclonal antibody known as an IL-17 inhibitor. Cosentyx (secukinumab) works similarly to steroids in that it lowers inflammation in your body to relieve symptoms like pain and swelling.
Is Cosentyx (secukinumab) a biologic?
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Yes, Cosentyx (secukinumab) is a type of biologic medication. Biologics are medications that are made from living sources, like cells, in the lab. Cosentyx (secukinumab) is a monoclonal antibody, which is a lab-made protein that's made from cells.
Is Cosentyx (secukinumab) an immunosuppressant?
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Cosentyx (secukinumab) acts like an immunosuppressant because works by blocking a protein (IL-17) in your immune system that's overly active. In doing so, this medication dampens the immune system and can make it harder for your body to fight off infections. But keep in mind that there are many types of immunosuppressants and they don't all have the same effect on your immune system. For example, Cosentyx (secukinumab) is less likely to raise your risk for infection compared to stronger immunosuppressants, such as organ transplant medications.
How long does Cosentyx (secukinumab) stay in your system?
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It takes about 5 months for most of Cosentyx (secukinumab) to leave your body after a single dose. This time-frame is estimated based on the half-life of Cosentyx (secukinumab) in people with PsO; it doesn't mean that this medication will continue to work well throughout this period. In order for Cosentyx (secukinumab) treat your condition, you'll typically need to take it monthly or as directed by your provider.
Does Cosentyx (secukinumab) cause hair loss?
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No, hair loss wasn't a reported side effect from people receiving Cosentyx (secukinumab) during clinical trials. Contact your provider if you notice hair loss while you're taking Cosentyx (secukinumab). They can examine you for other possible causes of hair loss.
Does Cosentyx (secukinumab) cause weight gain?
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No, Cosentyx (secukinumab) doesn't typically cause weight gain or weight loss. Contact your provider if you notice significant changes in weight while taking Cosentyx (secukinumab).
How long does it take for Cosentyx (secukinumab) to work?
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How long it takes for Cosentyx (secukinumab) to work can depend on what condition you're taking it to treat. For example, some people with psoriatic arthritis started to feel relief in as early as 3 weeks, though many experienced more noticeable improvements after 4 to 6 months of treatment. In a study of people with plaque psoriasis, most people saw clear or almost clear skin about 3 months after starting Cosentyx (secukinumab). Keep in mind that everyone responds to Cosentyx (secukinumab) differently. Follow up with your provider about how well Cosentyx (secukinumab) is working for your medical condition.
How long can Cosentyx (secukinumab) stay out of the fridge?
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If possible, you should keep Cosentyx (secukinumab) Sensoready Pens and prefilled syringes in the refrigerator until you're ready to use it. But if needed, you can leave the medication at room temperature for up to 4 days. Make sure to write the new 4-day expiration date on the medication box. If you don't use the medication before the 4-day expiration, throw it away.
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What are the risks and warnings for Cosentyx (secukinumab)?
Cosentyx (secukinumab) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Infections
Risk factors: Active, chronic, or recurrent infection | Having other conditions that raise your risk of infection
Cosentyx (secukinumab) can make it more difficult for your body to fight off germs. This raises your risk for bacterial, viral, or fungal infections that are harder to treat. Let your provider know if you feel sick during treatment. If you've an infection, they might ask you to stop taking Cosentyx (secukinumab) so your body can fightit off. Contact your provider if you develop symptoms of an infection, such as fever, cough, chills, and body aches.
Cosentyx (secukinumab) can also cause new or old tuberculosis (TB) infections to come back. You'll need to get tested for TB before you start this medication and get treated if it's confirmed that you have TB. Tell your provider about your medical conditions and medications to make sure Cosentyx (secukinumab) is safe to take.
Caution when getting vaccines
It's best to be up-to-date on all your vaccines before you start Cosentyx (secukinumab). Avoid getting live vaccines during treatment because it's not known whether they're safe to get while you're taking Cosentyx (secukinumab). Examples of live vaccines include Varivax (chickenpox vaccine) and MMR (measles, mumps, and rubella vaccine). Let your provider or pharmacist know that you're taking Cosentyx (secukinumab) before you get any vaccines.
Allergic and skin reactions
Risk factors: Allergy to latex (for Sensoready Pen and prefilled syringes)
It's possible to have a serious allergic reaction to Cosentyx (secukinumab). These allergic reactions can include difficulty breathing; hives; swelling of your face, lips, tongue, or throat; or any other symptom of anaphylaxis.
Tell your provider if you're allergic to latex because the cap on the prefilled syringe and Sensoready Pen contains latex. Get medical help right away if you have an allergic reaction to Cosentyx (secukinumab) at any time during treatment.
There have also been reports of eczema-like skin problems from Cosentyx (secukinumab). People who reported this had it happen days to months after the first dose of Cosentyx (secukinumab). Contact your provider if you notice changes in your skin (rash, hives, itchiness, redness, swelling).
Worsening of inflammatory bowel disease
In clinical studies, some people with inflammatory bowel disease (IBD) experienced worsening symptoms or IBD flare-ups while taking Cosentyx (secukinumab). Before starting, let your provider know if you have a history of IBD. Contact your provider if you have stomach pain, bloody stools, diarrhea or constipation that doesn't get better, or sudden weight loss while taking Cosentyx (secukinumab).
Cosentyx (secukinumab) dosage forms
Typical dosing for Cosentyx (secukinumab)
Adults
Plaque psoriasis (PsO) and hidradenitis suppurativa: The typical starting dose is 300 mg injected under the skin weekly for 5 weeks. After that, the maintenance dose is usually 300 mg injected monthly.
Psoriatic arthritis (PsA), ankylosing spondylitis (AS), and non-radiographic axial spondyloarthritis (nr-axSpA): The starting dose can be optional; if given, the typical dose is 150 mg injected under the skin (SQ) weekly for 5 weeks. After that, the maintenance dose is usually 150 mg injected under the skin monthly. If appropriate, your provider might raise your dose to 300 mg monthly.
Children
Cosentyx is approved for children to treat PsO (ages 6 years and older), PsA (ages 2 years and older), and enthesitis-related arthritis (ages 4 years and older).
Body weight 33 lbs to 110 lbs: The typical starting dose is 75 mg injected under the skin weekly for 5 weeks. After that, the maintenance dose is usually 75 mg injected monthly.
Body weight 110 lbs or more: The typical starting dose is 150 mg injected under the skin weekly for 5 weeks. After that, the maintenance dose is usually 150 mg injected monthly.
Cosentyx (secukinumab) can also be given as an injection through the veins for PsA, AS, and nr-axSpA for adults only. Your provider will calculate the dose based on your body weight. The injection is usually given by a healthcare provider in a clinic setting.
How much does Cosentyx (secukinumab) cost?
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Cosentyx (brand)
What are alternatives to Cosentyx (secukinumab)?
There are a number of medications that your doctor can prescribe in place of Cosentyx (secukinumab). Compare a few possible alternatives below.
Cosentyx (secukinumab)
Used for:
Plaque psoriasis (PsO) in people ages 6 years and older
Psoriatic arthritis (PsA) in people ages 2 years and older who weigh at least 33 lbs
Ankylosing spondylitis (AS) in adults
Non-radiographic axial spondyloarthritis (nr-axSpA) in adults
Enthesitis-related arthritis in people ages 4 years and older who weigh at least 33 lbs
Hidradenitis suppurativa in adults
$7477.74 Lowest GoodRx priceView Prices
Otezla (apremilast)
Used for:
Active psoriatic arthritis
Plaque psoriasis
Mouth sores from Behçet’s disease
$4705.73 Lowest GoodRx priceView Prices
Taltz (ixekizumab)
Used for:
Moderate-to-severe plaque psoriasis in people ages 6 years and older
Psoriatic arthritis (PsA) in adults
Ankylosing spondylitis (AS) in adults
Non-radiographic axial spondyloarthritis (nr-axSpA) in adults
View Prices
What is the latest news about Cosentyx (secukinumab)?
Cosentyx (secukinumab) images
This medicine is Yellow Carton.yellow - Cosentyx 2-Pack 150mg/mL Pre-Filled Pen Solution for Injection
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